The creation of a vertical building expansion with the lowest levels of the facility above the storm surge levels and the relocation of infrastructure equipment and systems to these elevated areas would greatly reduce the threat and risk of flooding and would be the best solution for continued operations of vital infrastructure systems during and after such events. The UH/CH Infrastructure Relocation became a five-phase mitigation plan. Only after the first four phases were complete could Phase Five, the Sabin Street Energy Plant begins. This project was unusually complex because it was constructed without interrupting electrical service to hospital facilities, where life safety is the prime consideration. The level of communication and cooperation among the design team, facilities personnel, and clinical staff was an exceptional example of project success. The future value in this system lies in the systems’ flexibility and robustness. The loss of a single generator, transformer, or automatic transfer switch does not result in a long emergency power outage. Most importantly, the major components are above flood level and MUSC hospitals are now better able to serve the Lowcountry community through severe storm conditions. Many lives will be saved because the hospitals are now equipped to continue to operate through extreme storm conditions.